Defence of doctoral thesis on porcine circovirus

Next 13 July 2010 (Tuesday), Carolina Rodríguez Cariño, PhD student of the CReSA, will defend her doctoral thesis entitled “Ultrastructural studies on Porcine Circovirus type 2 (PCV2) infection” directed by Dr Joaquim Segalés.

The thesis includes the first morphogenesis study of porcine circovirus type 2 (PCV2) on cell culture as well as the most detailed ultrastructural descriptions of lymph nodes from post-weaning multisystemic wasting syndrome (PMWS)  affected pigs.

Obtained results allowed to complement existing works on the PCV2 replication cycle in cell culture and to gain new insights on the pathogenesis of PMWS. The description of the intimate association between PCV2 and mitochondria is one of the major contributions of the present thesis.

PMWS is one of the most significant porcine diseases worldwide. This condition is clinically is characterized by growth retardation, weight loss, labored breathing, fever, diarrhea and death in nursery and/or fattening pigs. The essential causative agent is PCV2, the smallest virus known to infect animals. Lymphocyte depletion and infiltration of histiocytes and/or multinucleate giant cells in lymphoid tissues are the hallmark histological features that define the disease; in some cases, intracytoplasmic and intranuclear viral-like inclusions can be found macrophages. Ultrastructurally, PCV2 has been described as a non-enveloped virus of 12-23 nm in diameter.

The event will be held next Tuesday, 13 July 2010 (12:00 h) in the Veterinary School Auditorium (Universitat Autònoma de Barcelona).

To contact with the author of this thesis:

Carolina Rodríguez Cariño
PhD Student
Telephone no.: +34 93 581 45 87
Fax: +34 93 581 44 90
Edifici CReSA. Campus UAB
08193 Bellaterra (Barcelona) Spain

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