Doctoral thesis about new vaccine vectors

On December 2, 2011, Elisa Crisci, (PhD student of the CReSA) will defend her doctoral thesis entitled “Immunogenic properties of calicivirus-like particles as vaccine vectors”, directed by Dr Maria Montoya.

New subunit vaccines are getting a foothold in veterinary vaccinology and virus-like particles (VLPs) are one of the most appealing approaches opening up frontiers in animal vaccines.

VLPs are robust protein cages that mimic the overall structure of the native virions and have an important advantage in terms of safety. Rabbit haemorrhagic disease virus (RHDV) capsid protein is able to form RHDV-VLPs and these particles showed a strong immunogenicity and protected the natural host after a lethal challenge.

This thesis was aimed to study the potential immunogenicity of RHDV-VLPs as epitope carriers for viral disease in two different animal models. The immunogenicity of chimeric RHDV-VLPs was investigated in murine and porcine systems in vitro and in vivo. In conclusion, the thesis demonstrated the potential ability of RHDV-VLPs as against viral animal diseases.

The event will be held on December 2 (12:00h), in the Sala d’Actes of the Facultat de Veterinària (Universitat Autònoma de Barcelona).

To contact the author of this thesis:

Elisa Crisci
PhD Student
Phone: +34 935814527
Fax: +34 93581490
08193 Bellaterra (Barcelona) Spain

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