The association between consumption of antimicrobials and occurrence of resistance will be studied

This study from CReSA will investigate the presence of extended-spectrum cephalosporinase (ESC) producing E. coli and S. enterica in pigs, and evaluate the possible association between consumption of different antimicrobials and occurrence of resistantce.

The project entitled “Assessment of risk factors in relation with antimicrobial consumption associated to the emergence of cephalosporin resistance in food animals (AGL2011-28836)” will be funded by the Ministry of Science and Innovation (MICINN) from the R+D+I national Plan and will take three years  (2012-2015). Lourdes García-Migura, principal investigator of the project, belongs to the research group of the CReSA “Bacterial zoonotic infections and antimicrobial resistance”. The project will be done in collaboration with the Centro VISAVET of the Universidad Complutense de Madrid.

Spain is the second producer of pork products for human consumption in the European Union. Although cephalosporins are rarely used in pig farms, ceftiofur and cefquinome, a third and a fourth generation cephalosporins respectively, are licensed for treatment of systemic bacterial infections.

The worrisome of extended spectrum cephalosporinases (ESC) producing Escherichia coli and Salmonella enterica entering the food chain have raised the debate on the use of these type of antimicrobials for animal husbandry. Since the genes coding resistance to cephalosporins are generally associated to multi-drug resistant plasmids, selection of ESC producing E. coli and S. enterica might be driven by the use of unrelated compounds, such as sulphonamides, tetracycline or b-lactams antimicrobials commonly used in the pork industry.

This study intends to investigate the presence of ESC producing E. coli and S. enterica in fattening pigs (fattening units and farrow-to-finish farms), and evaluate the possible association between consumption of different antimicrobials and occurrence of ESC producing E. coli and S. enterica.

To contact the principal investigator of the project:

Lourdes García-Migura
Email: lourdes.migura@cresa.uab.cat
Phone no.: +34 93 581 45 59
Fax: +34 93 581 44 90
Edifici CReSA. Campus UAB
08193 Bellaterra (Barcelona) Spain

Recent papers by L. García Migura (2010-2011):  

Porcine and human community reservoirs of Enterococcus faecalis, Denmark. Larsen J, Schønheyder HC, Singh KV, Lester CH, Olsen SS, Porsbo LJ, Garcia-Migura L, Jensen LB, Bisgaard M, Murray BE, Hammerum AM. Emerg Infect Dis. 2011 Dec;17(12):2395-7.

Presence of glycopeptide-encoding plasmids in enterococcal isolates from food and humans in Denmark. Garcia-Migura L, Sanchez-Valenzuela AJ, Jensen LB. Foodborne Pathog Dis. 2011 Nov;8(11):1191-7.

Establishing Streptomycin Epidemiological Cut-Off Values for Salmonella and Escherichia coli. Garcia-Migura L, Sunde M, Karlsmose S, Veldman K, Schroeter A, Guerra B, Granier SA, Perrin-Guyomard A, Gicquel-Bruneau M, Franco A, Englund S, Teale C, Heiska H, Clemente L, Boerlin P, Moreno MA, Daignault D, Mevius D, Hendriksen RS, Aarestrup FM. Microb Drug Resist. 2011 Jul 12.

Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria. Werner G, Freitas AR, Coque TM, Sollid JE, Lester C, Hammerum AM, Garcia-Migura L, Jensen LB, Francia MV, Witte W, Willems RJ, Sundsfjord A. J Antimicrob Chemother. 2011 Feb;66(2):273-82.

Epidemiological investigation of Salmonella enterica serovar Kedougou in Thailand. Pornruangwong S, Hendriksen RS, Pulsrikarn C, Bangstrakulnonth A, Mikoleit M, Davies RH, Aarestrup FM, Garcia-Migura L. Foodborne Pathog Dis. 2011 Feb;8(2):203-11.

Porcine-origin gentamicin-resistant Enterococcus faecalis in humans, Denmark. Larsen J, Schønheyder HC, Lester CH, Olsen SS, Porsbo LJ, Garcia-Migura L, Jensen LB, Bisgaard M, Hammerum AM. Emerg Infect Dis. 2010 Apr;16(4):682-4.

A classification system for plasmids from enterococci and other Gram-positive bacteria. Jensen LB, Garcia-Migura L, Valenzuela AJ, Løhr M, Hasman H, Aarestrup FM. J Microbiol Methods. 2010 Jan;80(1):25-43.

 
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