PMWS clinical expression under field conditions is modulated by the pig genetic background

Post-weaning multisystemic wasting syndrome (PMWS) is one of the porcine circovirus type 2 (PCV2) associated diseases. Researchers of CReSA studied the effect of 3 different genetic boar lines on the expression of PMWS in their offspring.

The economic losses associated to this disease were of €900 million per year in the European Union, however the recent availability of vaccines in the market have demonstrated excellent results to counteract the disease.

Pig genetic has been pointed to influence disease expression. Farmers and veterinarians in the field have suggested that different pig breeds or genetic lines have different susceptibilities to PMWS.

The objective of the present study was to compare the effect of 3 different genetic boar lines on the expression of PMWS in their offspring. Sows from the same genetic line (37.5% Large White × 37.5% Duroc × 25% Landrace) located on two PMWS-affected farms (farm-1 and farm-2) were inseminated, using three different boar lines, namely:
  • A (100% Pietrain)
  • B (50% Large White x 50% Pietrain)
  • C (25% Large White x 75% Duroc)

Obtained results showed:

  • Overall, a total of 6.5% post-weaning mortality (PWM), and 4.3% post-weaning mortality associated to PMWS (PMWS-PWM) occurred in the monitored farms.
  • Pigs from boar line C showed the highest PWM (16.3%) and PMWS-PWM (12.4%), and the lowest body weight.
  • Pigs from boar line A showed the lowest PWM (1.8%) and the highest body weight.
  • Furthermore, PWM was also higher in piglets from farm-2 and from multiparous sows.
  • In farm-2, PMWS-PWM was higher in piglets from multiparous sows.
  • Finally, body weight was influenced by interactions between genetics and both farm and pig age, and was lower in piglets from farm-2.

This study represents a consistent observation of the genetic background effect on PMWS clinical expression under field conditions. However, further studies are needed to elucidate the exact role by which porcine genetics affect susceptibility/resistance to PMWS.

This paper has been published in: López-Soria S, Nofrarías M, Calsamiglia M, Espinal A, Valero O, Ramírez-Mendoza H, Mínguez A, Serrano JM, Marín O, Callén A, Segalés J. Post-weaning multisystemic wasting syndrome (PMWS) clinical expression under field conditions is modulated by the pig genetic background. Vet Microbiol. 2011 May 5;149(3-4):352-7.

To contact the author of this paper:

Sergio López Soria
Investigator
Email: sergio.lopez@cresa.uab.cat
Telephone no.: +34 93 581 44 95
Fax: +34 93 581 44 90
Edifici CReSA. Campus UAB
08193 Bellaterra (Barcelona) Spain

Download the full paper:

http://linkinghub.elsevier.com/retrieve/pii/S0378-1135(10)00582-1

 
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