Demonstrated correlation between TTSuV2 and classical swine fever

Researchers of CReSA have demonstrated that viral load and prevalence of Torque teno sus virus 2 are increased in pigs experimentally infected with classical swine fever virus.

Torque teno sus viruses (TTSuVs) are considered non-pathogenic viruses, although lately they have been linked to porcine circovirus diseases (mainly with porcine circovirus type 2-systemic disease, PCV2-SD). These associations point out a possible pathogenic role of TTSuVs or, alternatively, that TTSuV replication is up-regulated under disease conditions.

In order to further explore the association of TTSuVs with disease occurrence, TTSuVs prevalence and viral load were assessed before and after an experimental infection with a highly pathogenic classical swine fever virus (CSFV) isolate. Serum samples from 56 animals were analyzed by means of a real time quantitative PCR (qPCR) for TTSuV1 and TTSuV2 before and after (between 6 and 13 days post-inoculation) the CSFV challenge. Based on the post-infection clinical evolution and immune response against CSFV, the animals were divided into two groups: group I, with protecting immunity against CSFV and no clinical signs at the day of necropsy, and group II, with no detectable immune response against CSFV and moderate to severe clinical signs.

Results indicated that:

  • TTSuV2 load in serum, but not the one of TTSuV1, increased significantly after challenge with CSFV in the group of pigs with clinical signs, specifically in those with a moderate course of the disease.
  • TTSuV2 loads were inversely correlated with immunological responses against CSFV.
  • TTSuV1 loads were unchanged in all animal groups.

Therefore, this study emphasizes the different behaviour of both TTSuVs, as already found in the PCV2-SD background, and further supports the association of TTSuV2 with disease occurrence.

This paper has been recently published in: Aramouni M, Kekarainen T, Ganges L, Tarradas J, Segalés J. Increased viral load and prevalence of Torque teno sus virus 2 (TTSuV2) in pigs experimentally infected with classical swine fever virus (CSFV). Virus Res. 2012 Dec 27. doi:pii: S0168-1702(12)00472-8. 10.1016/j.virusres.2012.12.010. [Epub ahead of print] .

Download the full paper (PubMed): http://www.ncbi.nlm.nih.gov/pubmed/23274109

To contact the author of the paper:

Dr. Joaquim Segalés i Coma
Email: joaquim.segales@cresa.uab.cat
Phone no.: +34 93 581 44 92
Fax: +34 93 581 44 90
Edifici CReSA. Campus UAB
08193 Bellaterra (Cerdanyola del Vallès, Barcelona) Spain

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