The natural history of porcine circovirus type 2: from an inoffensive virus to a devastating disease?

A recently published review done by researchers from CReSA summarizes the current knowledge on the natural history of porcine circovirus type 2 (PCV2) infection and its related diseases.

The perception about PCV2 as a significant pathogen has markedly changed in the last 15 years. The ubiquitous nature of the virus, the retrospective evidence of this infection long before disease association, the multifactorial aetio-pathogenesis of PCV2-systemic disease (SD, formerly known as postweaning multisystemic wasting syndrome, PMWS) and the lack of consistent demonstration of Koch's postulates caused great controversy about the real causal capabilities of this virus.

The advent of vaccines against PCV2 radically changed such perception and this virus is nowadays regarded as a very important pig pathogen. Moreover, the current PCV2 vaccines are ones of the most widely used in pig producing countries. On the other hand, how the virus causes disease is still a not fully solved complex scientific question, but host, infection timing and the virus itself are pivotal factors to consider explaining disease presentation at an individual level.

The appearance of PCV2-SD as an epidemic problem at the end of 1990s or early-mid 2000s might be related with a number of known and unknown variables. Based on available data, the international trade of pigs may have played a major role in the dissemination of more susceptible swine genetic lines as well as in the global PCV2 genotype replacement (PCV2b over PCV2a) during such period.

This paper has been published in: Segalés J, Kekarainen T, Cortey, M. The natural history of porcine circovirus type 2: From an inoffensive virus to a devastating swine disease?, Veterinary Microbiology, Volume 165, Issues 1–2, 26 July 2013, Pages 13-20.

Download the full paper (ScienceDirect):

To contact the author of this paper:

Dr. Joaquim Segalés Coma
Telephone: +34 93 581 44 92
Fax: +34 93 581 44 90
Edifici CReSA. Campus UAB       
08193 Bellaterra (Cerdanyola del Vallès, Barcelona) Spain

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