Described a novel plasmid bearing resistance to beta-lactams in Haemophilus parasuis

A collaborative study between Dr Virginia Aragón, IRTA researcher at CReSA, and Dr Junkal Garmendia, CSIC researcher at the Institute of Agrobiotechnology from Navarra, has described a new plasmid in H. parasuis bearing resistance to beta-lactams, such as penicillins and cephalosporins. This plasmid was only detected in avirulent colonizers H. parasuis strains.

Studies of antimicrobial resistance typically focus on clinical isolates. Thus, a high degree of resistance to various antibiotics has been described in clinical H. parasuis strains isolated in Spain.

This new study, led by Dr Garmendia in collaboration with Dr Aragon, opens a new chapter in antimicrobial resistance studies. The existence of a new plasmid with resistance to beta-lactam antibiotics in non-virulent H. parasuis strains was discovered. Interestingly, this plasmid was not detected in strains isolated from the lesions of animals affected by Glässer's disease. This plasmid is small and is very stable in the strains; the maintenance of this plasmid does not involve a significant biological cost for the bacteria.

"These plasmids represent a reservoir of genes bearing resistance to beta-lactams that can be transferred to other pathogens or other bacteria" - explains Dr Aragon-. "The importance of the microbiota when antibiotic resistance surveillance studies are carried out should be emphasized”.

Dr. Aragón is in charge for the research on H. parasuis at IRTA.

Dr. Bruno Gonzalez-Zorn from the Universidad Complutense de Madrid is also a collaborator in this work, published in: Moleres J, Santos-López A, Lázaro I, Labairu J, Prat C, Ardanuy C, González-Zorn B, Aragón V, Garmendia J. Novel blaROB-1-Bearing Plasmid Conferring Resistance to β-Lactams in Haemophilus parasuis Isolates from Healthy Weaning Pigs. Appl Environ Microbiol. 2015 Mar 6. pii: AEM.03865-14.

H. parasuis, the causative agent of Glässer’s disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis and bronchopneumonia. Antibiotics are commonly used in disease control, and resistance to several antibiotics has been described in H. parasuis strains.


To contact Dr. Aragón:
Dr. Virginia Aragón
IRTA researcher at CReSA
Teléfono: +34 93 581 44 94
Campus UAB, Edifici CReSA s/n,  08193  Bellaterra (Cerdanyola del Vallès) Spain

¡Recommend this page!: